2026-04-29T07:22:55Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/72662024-11-29T15:41:55Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Evangelou, Konstantinos
author
Lougiakis, Nikolaos
author
Rizou, Sophia V
author
Kotsinas, Athanassios
author
Kletsas, Dimitris
author
Muñoz-Espín, Daniel
author
Kastrinakis, Nikolaos G
author
Pouli, Nicole
author
Marakos, Panagiotis
author
Townsend, Paul
author
Serrano Marugan, Manuel
author
Bartek, Jiri
author
Gorgoulis, Vassilis G
funder
Swedish Research Council for Health, Working Life and Welfare
funder
Danish National Research Foundation
funder
Novo Nordisk Foundation
2019-03-01T10:50:36Z
2019-03-01T10:50:36Z
2017-02
Aging Cell. 2017;16(1):192-197.
14749718
http://hdl.handle.net/20.500.12105/7266
28165661
10.1111/acel.12545
1474-9726
Aging cell
Cellular senescence contributes to organismal development, aging, and diverse pathologies, yet available assays to detect senescent cells remain unsatisfactory. Here, we designed and synthesized a lipophilic, biotin-linked Sudan Black B (SBB) analogue suitable for sensitive and specific, antibody-enhanced detection of lipofuscin-containing senescent cells in any biological material. This new hybrid histo-/immunochemical method is easy to perform, reliable, and universally applicable to assess senescence in biomedicine, from cancer research to gerontology.
eng
Sudan Black B
Aging
Biotin‐linked compounds
Immunohistochemistry
Senescence
Robust, universal biomarker assay to detect senescent cells in biological specimens
journal article
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