2026-04-29T07:23:39Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/72662024-11-29T15:41:55Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Evangelou, Konstantinos author Lougiakis, Nikolaos author Rizou, Sophia V author Kotsinas, Athanassios author Kletsas, Dimitris author Muñoz-Espín, Daniel author Kastrinakis, Nikolaos G author Pouli, Nicole author Marakos, Panagiotis author Townsend, Paul author Serrano Marugan, Manuel author Bartek, Jiri author Gorgoulis, Vassilis G author 2017-02 Cellular senescence contributes to organismal development, aging, and diverse pathologies, yet available assays to detect senescent cells remain unsatisfactory. Here, we designed and synthesized a lipophilic, biotin-linked Sudan Black B (SBB) analogue suitable for sensitive and specific, antibody-enhanced detection of lipofuscin-containing senescent cells in any biological material. This new hybrid histo-/immunochemical method is easy to perform, reliable, and universally applicable to assess senescence in biomedicine, from cancer research to gerontology. Aging Cell. 2017;16(1):192-197. 14749718 http://hdl.handle.net/20.500.12105/7266 28165661 10.1111/acel.12545 1474-9726 Aging cell Sudan Black B Aging Biotin‐linked compounds Immunohistochemistry Senescence Robust, universal biomarker assay to detect senescent cells in biological specimens