2026-07-23T17:42:41Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/72612024-09-27T08:39:05Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605col_20.500.12105_19607
Repisalud
author
Pellico, Juan
author
Lechuga-Vieco, Ana V.
author
Almarza, Elena
author
Hidalgo, Andres
author
Mesa-Nuñez, Cristina
author
Fernandez-Barahona, Irene
author
Quintana, Juan A.
author
Bueren, Juan
author
Enriquez, Jose Antonio
author
Ruiz-Cabello, Jesus
author
Herranz, Fernando
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
2019-02-28T15:52:37Z
2019-02-28T15:52:37Z
2017-10-16
Sci Rep. 2017; 7(1):13242
10.1038/s41598-017-12829-y
2045-2322
2045-2322
Scientific reports
29038592
http://hdl.handle.net/20.500.12105/7261
In vivo detection and quantification of inflammation is a major goal in molecular imaging. Furthermore, cell-specific detection of inflammation would be a tremendous advantage in the characterization of many diseases. Here, we show how this goal can be achieved through the synergistic combination of nanotechnology and nuclear imaging. One of the most remarkable features of this hybrid approach is the possibility to tailor the pharmacokinetics of the nanomaterial-incorporated biomolecule and radionuclide. A good example of this approach is the covalent binding of a large amount of a neutrophil-specific, hydrophobic peptide on the surface of 68Ga core-doped nanoparticles. This new nano-radiotracer has been used for non-invasive in vivo detection of acute inflammation with very high in vivo labelling efficiency, i.e. a large percentage of labelled neutrophils. Furthermore, we demonstrate that the tracer is neutrophil-specific and yields images of neutrophil recruitment of unprecedented quality. Finally, the nano-radiotracer was successfully detected in chronic inflammation in atherosclerosis-prone ApoE-/- mice after several weeks on a high-fat diet.
eng
In vivo imaging of lung inflammation with neutrophil-specific 68Ga nano-radiotracer
journal article
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