2026-06-14T03:35:59Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/72372024-11-29T20:06:56Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Marión, Rosa M
author
Lopez de Silanes, Isabel
author
Mosteiro, Lluc
author
Gamache, Benjamin
author
Abad, María
author
Guerra Carmen, Carmen
author
Megias Vazquez, Diego
author
Serrano Marugan, Manuel
author
Blasco , MA
funder
Botín Foundation
funder
Ministerio de Economía y Competitividad (España)
2019-02-26T12:07:39Z
2019-02-26T12:07:39Z
2017-02-14
Stem Cell Reports. 2017;8(2):460-475.
10.1016/j.stemcr.2017.01.001
2213-6711
22136711
Stem cell reports
28162998
http://hdl.handle.net/20.500.12105/7237
Reprogramming of differentiated cells into induced pluripotent stem cells has been recently achieved in vivo in mice. Telomeres are essential for chromosomal stability and determine organismal life span as well as cancer growth. Here, we study whether tissue dedifferentiation induced by in vivo reprogramming involves changes at telomeres. We find telomerase-dependent telomere elongation in the reprogrammed areas. Notably, we found highly upregulated expression of the TRF1 telomere protein in the reprogrammed areas, which was independent of telomere length. Moreover, TRF1 inhibition reduced in vivo reprogramming efficiency. Importantly, we extend the finding of TRF1 upregulation to pathological tissue dedifferentiation associated with neoplasias, in particular during pancreatic acinar-to-ductal metaplasia, a process that involves transdifferentiation of adult acinar cells into ductal-like cells due to K-Ras oncogene expression. These findings place telomeres as important players in cellular plasticity both during in vivo reprogramming and in pathological conditions associated with increased plasticity, such as cancer.
eng
ADM
TRF1
Cancer
Cellular plasticity
In vivo reprogramming
Regeneration
Stem cells
Telomeres
Transdifferentiation
tumorigenesis
Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis
journal article
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