2026-07-21T19:37:28Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/72292024-09-27T08:20:49Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Cruz-Adalia, Aránzazu
author
Ramirez-Santiago, Guillermo
author
Osuna-Pérez, Jesús
author
Torres-Torresano, Mónica
author
Zorita, Virginia
author
Martínez-Riaño, Ana
author
Boccasavia, Viola
author
Borroto, Aldo
author
Martinez del Hoyo, Gloria
author
Gonzalez-Granado, Jose Maria
author
Alarcón, Balbino
author
Sanchez-Madrid, Francisco
author
Veiga, Esteban
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Fundación Ramón Areces
funder
Unión Europea. Comisión Europea
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Centro de Investigación Biomedica en Red - CIBER
2019-02-25T11:39:15Z
2019-02-25T11:39:15Z
2017
Nat Commun. 2017; 8(1):1591
10.1038/s41467-017-01661-7
2041-1723
2041-1723
Nature communications
29147022
http://hdl.handle.net/20.500.12105/7229
Bacterial phagocytosis and antigen cross-presentation to activate CD8+ T cells are principal functions of professional antigen presenting cells. However, conventional CD4+ T cells also capture and kill bacteria from infected dendritic cells in a process termed transphagocytosis (also known as transinfection). Here, we show that transphagocytic T cells present bacterial antigens to naive CD8+ T cells, which proliferate and become cytotoxic in response. CD4+ T-cell-mediated antigen presentation also occurs in vivo in the course of infection, and induces the generation of central memory CD8+ T cells with low PD-1 expression. Moreover, transphagocytic CD4+ T cells induce protective anti-tumour immune responses by priming CD8+ T cells, highlighting the potential of CD4+ T cells as a tool for cancer immunotherapy.
eng
Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses
journal article
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