2026-07-21T19:38:19Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/72292024-09-27T08:20:49Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Cruz-Adalia, Aránzazu author Ramirez-Santiago, Guillermo author Osuna-Pérez, Jesús author Torres-Torresano, Mónica author Zorita, Virginia author Martínez-Riaño, Ana author Boccasavia, Viola author Borroto, Aldo author Martinez del Hoyo, Gloria author Gonzalez-Granado, Jose Maria author Alarcón, Balbino author Sanchez-Madrid, Francisco author Veiga, Esteban author 2017 Bacterial phagocytosis and antigen cross-presentation to activate CD8+ T cells are principal functions of professional antigen presenting cells. However, conventional CD4+ T cells also capture and kill bacteria from infected dendritic cells in a process termed transphagocytosis (also known as transinfection). Here, we show that transphagocytic T cells present bacterial antigens to naive CD8+ T cells, which proliferate and become cytotoxic in response. CD4+ T-cell-mediated antigen presentation also occurs in vivo in the course of infection, and induces the generation of central memory CD8+ T cells with low PD-1 expression. Moreover, transphagocytic CD4+ T cells induce protective anti-tumour immune responses by priming CD8+ T cells, highlighting the potential of CD4+ T cells as a tool for cancer immunotherapy. Nat Commun. 2017; 8(1):1591 10.1038/s41467-017-01661-7 2041-1723 2041-1723 Nature communications 29147022 http://hdl.handle.net/20.500.12105/7229 Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses