2026-06-14T06:44:12Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/72282024-09-27T10:16:35Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19607
Repisalud
author
Gasull-Camós, Júlia
author
Soto-Montenegro, Maria Luisa
author
Casquero-Veiga, Marta
author
Desco, Manuel
author
Artigas, Francesc
author
Castañé, Anna
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Government of Catalonia (España)
funder
Comunidad de Madrid (España)
funder
Centro de Investigación Biomedica en Red - CIBER
2019-02-25T11:01:30Z
2019-02-25T11:01:30Z
2017
Int J Neuropsychopharmacol. 2017; 20(12):988-993
10.1093/ijnp/pyx067
1469-5111
1461-1457
The international journal of neuropsychopharmacology
29016806
http://hdl.handle.net/20.500.12105/7228
Background: Glutamatergic neurotransmission has emerged as a novel target in antidepressant drug development, with a critical role of the ventral anterior cingulate cortex. We recently reported that blockade of the astrocytic glutamate transporter GLT-1 with dihydrokainic acid in infralimbic cortex (rodent equivalent of ventral anterior cingulate cortex), but not in the adjacent prelimbic cortex, evoked robust antidepressant-like effects through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor activation and increased serotonin release. Methods: 2-deoxy-2-[18F]-fluoro-D-glucose-positron emission tomography and computed tomography in 36 male Wistar rats microinfused bilaterally in prelimbic cortex or infralimbic cortex with dihydrokainic acid or vehicle. Results: Dihydrokainic acid microinfusion in infralimbic cortex and prelimbic cortex evoked dramatically different regional patterns of subcortical activity. In infralimbic cortex, dihydrokainic acid selectively affected midbrain areas, whereas in prelimbic cortex it affected the basal ganglia, the thalamus, and both superior and inferior colliculi. Conclusions: These results highlight the differential connectivity of infralimbic and prelimbic cortex with subcortical brain regions and support the involvement of infralimbic cortex-midbrain pathway in the antidepressant-like effects of dihydrokainic acid.
eng
FDG-PET
Dihydrokainic acid
Glutamate transporter-1
Infralimbic
Prelimbic
Differential Patterns of Subcortical Activity Evoked by Glial GLT-1 Blockade in Prelimbic and Infralimbic Cortex: Relationship to Antidepressant-Like Effects in Rats
journal article
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DifferentialPatternsSubcorticalActivity_2017.pdf
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https://repisalud.isciii.es/bitstreams/090654c6-102b-446e-ac7f-4971f6a50efc/download
File
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DifferentialPatternsSubcorticalActivity_2017.pdf.txt