2026-06-14T06:44:10Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/72272024-09-27T09:18:04Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Ilacqua, Nicolò
author
Sanchez-Alvarez, Miguel
author
Bachmann, Magdalena
author
Costiniti, Veronica
author
del Pozo, Miguel Angel
author
Giacomello, Marta
funder
Fondazione Cariparo
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Worldwide Cancer Research Foundation
funder
Fundación ProCNIC
2019-02-25T09:08:29Z
2019-02-25T09:08:29Z
2017
Front Cell Dev Biol. 2017; 5:107
10.3389/fcell.2017.00107
2296-634X
Frontiers in cell and developmental biology
29312934
http://hdl.handle.net/20.500.12105/7227
Mitochondria-endoplasmic reticulum (ER) contacts (MERCs) are sites at which the outer mitochondria membrane and the Endoplasmic Reticulum surface run in parallel at a constant distance. The juxtaposition between these organelles determines several intracellular processes such as to name a few, Ca2+ and lipid homeostasis or autophagy. These specific tasks can be exploited thanks to the enrichment (or re-localization) of dedicated proteins at these interfaces. Recent proteomic studies highlight the tissue specific composition of MERCs, but the overall mechanisms that control MERCs plasticity remains unclear. Understanding how proteins are targeted at these sites seems pivotal to clarify such contextual function of MERCs. This review aims to summarize the current knowledge on protein localization at MERCs and the possible contribution of the mislocalization of MERCs components to human disorders.
eng
ER stress
Lipid rafts
Mitochondria-ER contact sites
Post-translational modifications
Protein targeting
Protein Localization at Mitochondria-ER Contact Sites in Basal and Stress Conditions
journal article
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URL
https://repisalud.isciii.es/bitstreams/f9ac0404-aaba-45b8-83f7-41b03073fda2/download
File
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ProteinLocalizationMitochondria-ER_2017.pdf
URL
https://repisalud.isciii.es/bitstreams/eda0eaf2-704b-49f7-9b22-a781ce06985e/download
File
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ProteinLocalizationMitochondria-ER_2017.pdf.txt