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oai:repisalud.isciii.es:20.500.12105/72272024-09-27T09:18:04Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Ilacqua, Nicolò author Sanchez-Alvarez, Miguel author Bachmann, Magdalena author Costiniti, Veronica author del Pozo, Miguel Angel author Giacomello, Marta author 2017 Mitochondria-endoplasmic reticulum (ER) contacts (MERCs) are sites at which the outer mitochondria membrane and the Endoplasmic Reticulum surface run in parallel at a constant distance. The juxtaposition between these organelles determines several intracellular processes such as to name a few, Ca2+ and lipid homeostasis or autophagy. These specific tasks can be exploited thanks to the enrichment (or re-localization) of dedicated proteins at these interfaces. Recent proteomic studies highlight the tissue specific composition of MERCs, but the overall mechanisms that control MERCs plasticity remains unclear. Understanding how proteins are targeted at these sites seems pivotal to clarify such contextual function of MERCs. This review aims to summarize the current knowledge on protein localization at MERCs and the possible contribution of the mislocalization of MERCs components to human disorders. Front Cell Dev Biol. 2017; 5:107 10.3389/fcell.2017.00107 2296-634X Frontiers in cell and developmental biology 29312934 http://hdl.handle.net/20.500.12105/7227 ER stress Lipid rafts Mitochondria-ER contact sites Post-translational modifications Protein targeting Protein Localization at Mitochondria-ER Contact Sites in Basal and Stress Conditions