2026-04-27T03:42:44Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/72232024-09-27T09:19:41Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Davidson, Sean M
author
Ferdinandy, Péter
author
Andreadou, Ioanna
author
Bøtker, Hans Erik
author
Heusch, Gerd
author
Ibáñez, Borja
author
Ovize, Michel
author
Schulz, Rainer
author
Yellon, Derek M
author
Hausenloy, Derek J
author
Garcia-Dorado, David
funder
Unión Europea. European Cooperation in Science and Technology (COST)
funder
National Institute for Health Research (Reino Unido)
funder
Danish Council for Strategic Research
funder
Novo Nordisk Foundation
funder
Ministry of Human Capacities (Hungria)
funder
Deutsche Forschungsgemeinschaft (Alemania)
funder
British Heart Foundation
funder
Ministry of Health (Singapore)
funder
Ministry of Education Academic Research (Singapur)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2019-02-25T08:04:44Z
2019-02-25T08:04:44Z
2019-01-08
J Am Coll Cardiol. 2019; 73(1):89-99
07351097
http://hdl.handle.net/20.500.12105/7223
30621955
10.1016/j.jacc.2018.09.086
1558-3597
Journal of the American College of Cardiology
Many treatments have been identified that confer robust cardioprotection in experimental animal models of acute ischemia and reperfusion injury. However, translation of these cardioprotective therapies into the clinical setting of acute myocardial infarction (AMI) for patient benefit has been disappointing. One important reason might be that AMI is multifactorial, causing cardiomyocyte death via multiple mechanisms, as well as affecting other cell types, including platelets, fibroblasts, endothelial and smooth muscle cells, and immune cells. Many cardioprotective strategies act through common end-effectors and may be suboptimal in patients with comorbidities. In this regard, emerging data suggest that optimal cardioprotection may require the combination of additive or synergistic multitarget therapies. This review will present an overview of the state of cardioprotection today and provide a roadmap for how we might progress towards successful clinical use of cardioprotective therapies following AMI, focusing on the rational combination of judiciously selected, multitarget therapies. This paper emerged as part of the discussions of the European Union (EU)-CARDIOPROTECTION Cooperation in Science and Technology (COST) Action, CA16225.
eng
Cardioprotection
Ischemia
Myocardial infarction
Reperfusion
Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury: JACC Review Topic of the Week
journal article
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MultitargetStrategiesReducemMyocardial_2019.pdf
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MultitargetStrategiesReducemMyocardial_2019.pdf.txt