2026-06-14T03:30:23Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/72212024-09-27T09:42:16Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Gómez de Cedrón, Marta
author
Acin-Perez, Rebeca
author
Sánchez-Martínez, Ruth
author
Molina, Susana
author
Herranz, Jesús
author
Feliu, Jaime
author
Reglero, Guillermo
author
Enriquez, Jose Antonio
author
Ramírez de Molina, Ana
funder
Ministerio de Economía y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
2019-02-22T14:26:16Z
2019-02-22T14:26:16Z
2017
Mol Oncol. 2017; 11(12):1768-1787
10.1002/1878-0261.12142
1878-0261
1574-7891
Molecular oncology
28981199
http://hdl.handle.net/20.500.12105/7221
Cancer cell survival and metastasis are dependent on metabolic reprogramming that is capable of increasing resistance to oxidative and energetic stress. Targeting these two processes can be crucial for cancer progression. Herein, we describe the role of microRNA-661 (miR661) as epigenetic regulator of colon cancer (CC) cell metabolism. MicroR661 induces a global increase in reactive oxygen species, specifically in mitochondrial superoxide anions, which appears to be mediated by decreased carbohydrate metabolism and pentose phosphate pathway, and by a higher dependency on mitochondrial respiration. MicroR661 overexpression in non-metastatic human CC cells induces an epithelial-to-mesenchymal transition phenotype, and a reduced tolerance to metabolic stress. This seems to be a general effect of miR661 in CC, since metastatic CC cell metabolism is also compromised upon miR661 overexpression. We propose hexose-6-phosphate dehydrogenase and pyruvate kinase M2 as two key players related to the observed metabolic reprogramming. Finally, the clinical relevance of miR661 expression levels in stage-II and III CC patients is discussed. In conclusion, we propose miR661 as a potential modulator of redox and metabolic homeostasis in CC.
eng
Bioenergetics
Colon cancer
Metabolomics
miR
Oxidative stress
MicroRNA-661 modulates redox and metabolic homeostasis in colon cancer
journal article
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URL
https://repisalud.isciii.es/bitstreams/495679c9-a26f-491c-8720-4e68a4f8ac06/download
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MicroRNA‐661ModulatesRedox_2017.pdf
URL
https://repisalud.isciii.es/bitstreams/258b050f-ce69-4fce-b568-a6cb578aeb22/download
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MicroRNA‐661ModulatesRedox_2017.pdf.txt