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oai:repisalud.isciii.es:20.500.12105/72122024-11-28T16:01:40Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_2173com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_19597col_20.500.12105_16938col_20.500.12105_16980

00925njm 22002777a 4500 dc Bustos-Morán, Eugenio author Blas-Rus, Noelia author Alcaraz-Serna, Ana author Iborra, Salvador author González-Martínez, José author Malumbres Martinez, Marcos author Sanchez-Madrid, Francisco author 2019-02-18 Aurora A is a serine/threonine kinase whose role in cell cycle progression and tumour generation has been widely studied. Recent work has revealed an unexpected function for Aurora A during CD4+ T cell activation and, also, in graft versus host disease development. However, it remains unknown whether Aurora A is involved in CD8+ T cell effector function and in cytotoxic T lymphocyte-mediated antiviral response. Here, we show that Aurora A chemical inhibition leads to an impairment of both the peptide-specific cytotoxicity and the degranulation activity of CD8+ T cells. This finding was similarly proven for both mice and human CD8+ CTL activity. As a result of Aurora A blockade, we detected a reduction in the expression induced by T cell activation of genes classically related to the effector function of cytotoxic T lymphocytes such as granzyme B or perforin1. Finally, we have found that Aurora A is necessary for CD8+ T cell-mediated antiviral response, in an in vivo model of vaccinia virus infection. Thus, we can conclude that Aurora A activity is, indeed, needed for the proper effector function of cytotoxic T lymphocytes and for their activity against viral threats. Sci Rep. 2019; 9(1):2211 10.1038/s41598-019-38647-y 2045-2322 2045-2322 Scientific reports 30778113 http://hdl.handle.net/20.500.12105/7212 Aurora A controls CD8+ T cell cytotoxic activity and antiviral response