2026-04-26T23:29:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/72042024-11-29T19:19:41Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Bartolini, Giorgia
author
Sánchez-Alcañiz, Juan Antonio
author
Osório, Catarina
author
Valiente, Manuel
author
García-Frigola, Cristina
author
Marín, Oscar
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Ministerio de Ciencia y Tecnología (España)
2019-02-21T09:33:20Z
2019-02-21T09:33:20Z
2017
Cell Rep. 2017 ;18(5):1157-1170.
22111247
http://hdl.handle.net/20.500.12105/7204
28147272
10.1016/j.celrep.2016.12.089
2211-1247
Cell reports
Neural circuits in the cerebral cortex consist of excitatory pyramidal cells and inhibitory interneurons. These two main classes of cortical neurons follow largely different genetic programs, yet they assemble into highly specialized circuits during development following a very precise choreography. Previous studies have shown that signals produced by pyramidal cells influence the migration of cortical interneurons, but the molecular nature of these factors has remained elusive. Here, we identified Neuregulin 3 (Nrg3) as a chemoattractive factor expressed by developing pyramidal cells that guides the allocation of cortical interneurons in the developing cortical plate. Gain- and loss-of-function approaches reveal that Nrg3 modulates the migration of interneurons into the cortical plate in a process that is dependent on the tyrosine kinase receptor ErbB4. Perturbation of Nrg3 signaling in conditional mutants leads to abnormal lamination of cortical interneurons. Nrg3 is therefore a critical mediator in the assembly of cortical inhibitory circuits.
eng
Erbb4
GABA
Cerebral cortex
Cortical plate
Inhibition
Interneuron
Lamination
Migration
Neuregulins
Pyramidal cell
Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons
journal article
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