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oai:repisalud.isciii.es:20.500.12105/72042024-11-29T19:19:41Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Bartolini, Giorgia author Sánchez-Alcañiz, Juan Antonio author Osório, Catarina author Valiente, Manuel author García-Frigola, Cristina author Marín, Oscar author 2017 Neural circuits in the cerebral cortex consist of excitatory pyramidal cells and inhibitory interneurons. These two main classes of cortical neurons follow largely different genetic programs, yet they assemble into highly specialized circuits during development following a very precise choreography. Previous studies have shown that signals produced by pyramidal cells influence the migration of cortical interneurons, but the molecular nature of these factors has remained elusive. Here, we identified Neuregulin 3 (Nrg3) as a chemoattractive factor expressed by developing pyramidal cells that guides the allocation of cortical interneurons in the developing cortical plate. Gain- and loss-of-function approaches reveal that Nrg3 modulates the migration of interneurons into the cortical plate in a process that is dependent on the tyrosine kinase receptor ErbB4. Perturbation of Nrg3 signaling in conditional mutants leads to abnormal lamination of cortical interneurons. Nrg3 is therefore a critical mediator in the assembly of cortical inhibitory circuits. Cell Rep. 2017 ;18(5):1157-1170. 22111247 http://hdl.handle.net/20.500.12105/7204 28147272 10.1016/j.celrep.2016.12.089 2211-1247 Cell reports Erbb4 GABA Cerebral cortex Cortical plate Inhibition Interneuron Lamination Migration Neuregulins Pyramidal cell Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons