2026-08-05T15:45:11Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/71932024-09-27T22:32:35Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Trento, Alfonsina
author
Rodríguez-Fernández, Rosa
author
González-Sánchez, María I
author
González-Martínez, Felipe
author
Mas-Lloret, Vicente
author
Vazquez-Alcaraz, Monica
author
Palomo-Sanz, Concepcion
author
Melero, Jose Antonio
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
2019-02-20T11:33:09Z
2019-02-20T11:33:09Z
2017-11
Front Microbiol. 2017 Nov 22;8:2301.
10.3389/fmicb.2017.02301
1664-302X
Frontiers in microbiology
29213258
http://hdl.handle.net/20.500.12105/7193
The influence of age and maternal antibodies on the antibody responses to human respiratory syncytial virus (hRSV) glycoproteins in very young children has been a matter of controversy. Both, immaturity of the immune system at very early age and suppression of the host immune response by high level of maternal antibodies have been claimed to limit the host antibody response to virus infection and to jeopardize the use of hRSV vaccines under development in that age group. Hence, the antibody responses to the two major hRSV glycoproteins (F and G) were evaluated in children younger than 2 years, hospitalized with laboratory confirmed hRSV bronchiolitis. A strong negative correlation was found between the titre of circulating ELISA antibodies directed against either prefusion or postfusion F in the acute phase, but not age, and their fold change at convalescence. These changes correlated also with the level of circulating neutralizing antibodies in sera. As reported in adults, most neutralizing antibodies in a subset of tested sera could not be depleted with postfusion F, suggesting that they were mostly directed against prefusion-specific epitopes. In contrast, a weak negative association was found for group-specific anti-G antibodies in the acute phase and their fold change at convalescence only after correcting for the antigenic group of the infecting virus. In addition, large discrepancies were observed in some individuals between the antibody responses specific for F and G glycoproteins. These results illustrate the complexity of the anti-hRSV antibody responses in children experiencing a primary severe infection and the influence of preexisting maternal antibodies on the host response, factors that should influence hRSV serological studies as well as vaccine development.
eng
Antibody specificity
Bronchiolitis
Glycoproteins
Immune responses
Respiratory syncytial virus infections
Viral
The Complexity of Antibody Responses Elicited against the Respiratory Syncytial Virus Glycoproteins in Hospitalized Children Younger than 2 Years
journal article
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TheComplexityOfAntibody_2017.pdf
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TheComplexityOfAntibody_2017.pdf.txt