2026-06-14T03:29:40Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/71852024-09-27T22:24:11Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609col_20.500.12105_19617
Repisalud
author
Magro-Lopez, Esmeralda
author
Guijarro, Trinidad
author
Martinez, Isidoro
author
Martin-Vicente, Maria
author
Liste-Noya, Isabel
author
Zambrano, Alberto
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia e Innovación (España)
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
2019-02-19T15:14:32Z
2019-02-19T15:14:32Z
2017-12-10
Viruses. 2017 Dec 10;9(12). pii: E379.
10.3390/v9120379
1999-4915
Viruses
29232863
http://hdl.handle.net/20.500.12105/7185
Human respiratory syncytial virus (HRSV) is a major cause of serious pediatric respiratory diseases that lacks effective vaccine or specific therapeutics. Although our understanding about HRSV biology has dramatically increased during the last decades, the need for adequate models of HRSV infection is compelling. We have generated a two-dimensional minilung from human embryonic stem cells (hESCs). The differentiation protocol yielded at least six types of lung and airway cells, although it is biased toward the generation of distal cells. We show evidence of HRSV replication in lung cells, and the induction of innate and proinflammatory responses, thus supporting its use as a model for the study of HRSV-host interactions.
eng
Epithelial cells
Human embryonic stem cells
Minilung
Respiratory syncytial virus
A Two-Dimensional Human Minilung System (Model) for Respiratory Syncytial Virus Infections
research article
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URL
https://repisalud.isciii.es/bitstreams/b5ac3535-a4c1-4258-b51b-488e633a6564/download
File
MD5
26637577512a7877e315466cf437588b
1223074
application/pdf
ATWoDimensionalHuman_2017.pdf
URL
https://repisalud.isciii.es/bitstreams/95aff294-e169-40c4-8efc-3d95d3f62332/download
File
MD5
6a045ecad837fd6e844049e59bdb0a1a
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text/plain
ATWoDimensionalHuman_2017.pdf.txt