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oai:repisalud.isciii.es:20.500.12105/71852024-09-27T22:24:11Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609col_20.500.12105_19617

00925njm 22002777a 4500 dc Magro-Lopez, Esmeralda author Guijarro, Trinidad author Martinez, Isidoro author Martin-Vicente, Maria author Liste-Noya, Isabel author Zambrano, Alberto author 2017-12-10 Human respiratory syncytial virus (HRSV) is a major cause of serious pediatric respiratory diseases that lacks effective vaccine or specific therapeutics. Although our understanding about HRSV biology has dramatically increased during the last decades, the need for adequate models of HRSV infection is compelling. We have generated a two-dimensional minilung from human embryonic stem cells (hESCs). The differentiation protocol yielded at least six types of lung and airway cells, although it is biased toward the generation of distal cells. We show evidence of HRSV replication in lung cells, and the induction of innate and proinflammatory responses, thus supporting its use as a model for the study of HRSV-host interactions. Viruses. 2017 Dec 10;9(12). pii: E379. 10.3390/v9120379 1999-4915 Viruses 29232863 http://hdl.handle.net/20.500.12105/7185 Epithelial cells Human embryonic stem cells Minilung Respiratory syncytial virus A Two-Dimensional Human Minilung System (Model) for Respiratory Syncytial Virus Infections