2026-08-29T09:17:17Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/71802025-04-10T12:44:01Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Martin-Vicente, Maria
author
Medrano, Luz Maria
author
Resino, Salvador
author
García-Sastre, Adolfo
author
Martinez, Isidoro
funder
Instituto de Salud Carlos III
2019-02-19T10:05:07Z
2019-02-19T10:05:07Z
2017-09
Front Immunol. 2017 Sep 22;8:1187
10.3389/fimmu.2017.01187
1664-3224
Frontiers in immunology
29018447
http://hdl.handle.net/20.500.12105/7180
TRIM25 is an E3 ubiquitin ligase enzyme that is involved in various cellular processes, including regulation of the innate immune response against viruses. TRIM25-mediated ubiquitination of the cytosolic pattern recognition receptor RIG-I is an essential step for initiation of the intracellular antiviral response and has been thoroughly documented. In recent years, however, additional roles of TRIM25 in early innate immunity are emerging, including negative regulation of RIG-I, activation of the melanoma differentiation-associated protein 5-mitochondrial antiviral signaling protein-TRAF6 antiviral axis and modulation of p53 levels and activity. In addition, the ability of TRIM25 to bind RNA may uncover new mechanisms by which this molecule regulates intracellular signaling and/or RNA virus replication.
eng
E3 ubiquitin ligase
TRIM25
Innate immunity
Ubiquitination
Virus
TRIM25 in the Regulation of the Antiviral Innate Immunity
research article
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TRIM25InTheRegulation_2017.pdf
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TRIM25InTheRegulation_2017.pdf.txt