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00925njm 22002777a 4500 dc Martin-Vicente, Maria author Medrano, Luz Maria author Resino, Salvador author García-Sastre, Adolfo author Martinez, Isidoro author 2017-09 TRIM25 is an E3 ubiquitin ligase enzyme that is involved in various cellular processes, including regulation of the innate immune response against viruses. TRIM25-mediated ubiquitination of the cytosolic pattern recognition receptor RIG-I is an essential step for initiation of the intracellular antiviral response and has been thoroughly documented. In recent years, however, additional roles of TRIM25 in early innate immunity are emerging, including negative regulation of RIG-I, activation of the melanoma differentiation-associated protein 5-mitochondrial antiviral signaling protein-TRAF6 antiviral axis and modulation of p53 levels and activity. In addition, the ability of TRIM25 to bind RNA may uncover new mechanisms by which this molecule regulates intracellular signaling and/or RNA virus replication. Front Immunol. 2017 Sep 22;8:1187 10.3389/fimmu.2017.01187 1664-3224 Frontiers in immunology 29018447 http://hdl.handle.net/20.500.12105/7180 E3 ubiquitin ligase TRIM25 Innate immunity Ubiquitination Virus TRIM25 in the Regulation of the Antiviral Innate Immunity