2026-05-20T23:00:57Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/71722024-09-27T22:21:46Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Díaz, Luis Adrian
author
Albrieu Llinás, Guillermo
author
Vazquez, Ana
author
Tenorio, Antonio
author
Contigiani, Marta Silvia
funder
Ministerio de Ciencia y Tecnología (Argentina)
funder
National Scientific and Technical Research Council (Argentina)
funder
National University of Córdoba (Argentina)
funder
Instituto de Salud Carlos III
2019-02-12T15:10:21Z
2019-02-12T15:10:21Z
2012-01
PLoS Negl Trop Dis. 2012 Jan;6(1):e1489
10.1371/journal.pntd.0001489
1935-2735
PLoS neglected tropical diseases
22303490
http://hdl.handle.net/20.500.12105/7172
St. Louis encephalitis virus is a complex zoonoses. In 2005, 47 laboratory-confirmed and probable clinical cases of SLEV infection were reported in Córdoba, Argentina. Although the causes of 2005 outbreak remain unknown, they might be related not only to virological factors, but also to ecological and environmental conditions. We hypothesized that one of the factors for SLE reemergence in Córdoba, Argentina, was the introduction of a new SLEV genotype (SLEV genotype III), with no previous activity in the area. In order to evaluate this hypothesis we carried out a molecular characterization of SLEV detections from mosquitoes collected between 2001 and 2004 in Córdoba city. A total of 315 mosquito pools (11,002 individuals) including 12 mosquitoes species were analyzed. Overall, 20 pools (8 mosquitoes species) were positive for SLEV. During this study, genotypes II, V and VII were detected. No mosquito pool infected with genotype III was detected before the 2005 outbreak. Genotype V was found every year and in the 8 sampled sites. Genotypes II and VII showed limited temporal and spatial activities. We cannot dismiss the association of genotype II and V as etiological agents during the outbreak. However, the silent circulation of other SLEV strains in Córdoba city before the 2005 outbreak suggests that the introduction of genotype III was an important factor associated to this event. Not mutually exclusive, other factors such as changes in avian hosts and mosquitoes vectors communities, driven by climatic and environmental modifications, should also be taken into consideration in further studies.
eng
Silent circulation of St. Louis encephalitis virus prior to an encephalitis outbreak in Cordoba, Argentina (2005)
journal article
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URL
https://repisalud.isciii.es/bitstreams/9c829cbf-e203-4922-9967-41b9f7c3804e/download
File
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SilentCirculationOfStLouis_2012.pdf
URL
https://repisalud.isciii.es/bitstreams/cc394c75-3921-42c7-857f-0f3734408f2a/download
File
MD5
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text/plain
SilentCirculationOfStLouis_2012.pdf.txt