2026-06-14T12:44:48Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/71562024-09-27T08:01:12Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Palacios-Rubio, Julián author Marina-Breysse, Manuel author Quintanilla, Jorge G. author Gil-Perdomo, José Miguel author Juárez-Fernández, Miriam author Garcia-Gonzalez, Inés author Rial-Bastón, Verónica author Corcobado, María Carmen author Espinosa, María Carmen author Ruiz, Francisco author Gómez-Mascaraque Pérez, Francisco author Bringas-Bollada, María author Lillo-Castellano, Jose Maria author Pérez-Castellano, Nicasio author Martínez-Sellés, Manuel author López de Sá, Esteban author Martín-Benítez, Juan Carlos author Pérez-Villacastín, Julián author Filgueiras-Rama, David author 2018-12 OBJECTIVE: Ventricular fibrillation (VF)-related sudden cardiac death (SCD) is a leading cause of mortality and morbidity. Current biological and imaging parameters show significant limitations on predicting cerebral performance at hospital admission. The AWAKE study (NCT03248557) is a multicentre observational study to validate a model based on spectral ECG analysis to early predict cerebral performance and survival in resuscitated comatose survivors. METHODS: Data from VF ECG tracings of patients resuscitated from SCD will be collected using an electronic Case Report Form. Patients can be either comatose (Glasgow Coma Scale - GCS - ≤8) survivors undergoing temperature control after return of spontaneous circulation (RoSC), or those who regain consciousness (GCS=15) after RoSC; all admitted to Intensive Cardiac Care Units in 4 major university hospitals. VF tracings prior to the first direct current shock will be digitized and analyzed to derive spectral data and feed a predictive model to estimate favorable neurological performance (FNP). The results of the model will be compared to the actual prognosis. RESULTS: The primary clinical outcome is FNP during hospitalization. Patients will be categorized into 4 subsets of neurological prognosis according to the risk score obtained from the predictive model. The secondary clinical outcomes are survival to hospital discharge, and FNP and survival after 6 months of follow-up. The model-derived categorisation will be also compared with clinical variables to assess model sensitivity, specificity, and accuracy. CONCLUSIONS: A model based on spectral analysis of VF tracings is a promising tool to obtain early prognostic data after SCD. Arch Cardiol Mex. 2018; 88(5):460-467 10.1016/j.acmx.2018.05.003 1665-1731 1405-9940 Archivos de cardiologia de Mexico 29885765 http://hdl.handle.net/20.500.12105/7156 Análisis de onda Coma España Fibrilación ventricular Muerte súbita Prognosis Pronóstico Reanimación Resuscitation Spain Sudden cardiac death Ventricular fibrillation Wavelet analysis Early prognostic value of an Algorithm based on spectral Variables of Ventricular fibrillAtion from the EKG of patients with suddEn cardiac death: A multicentre observational study (AWAKE)