2026-08-29T20:41:54Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/71272024-09-27T08:47:51Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Herrero-Galan, Elas
author
Martinez-Martin, Ines
author
Alegre-Cebollada, Jorge
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
European Research Area Network on Cardiovascular Diseases
funder
Fundación ProCNIC
2019-02-06T08:29:08Z
2019-02-06T08:29:08Z
2018-12-12
Redox Biol. 2018; 21:101074
10.1016/j.redox.2018.101074
2213-2317
22132317
Redox biology
30584979
http://hdl.handle.net/20.500.12105/7127
The nanomechanics of sarcomeric proteins is a key contributor to the mechanical output of muscle. Among them, titin emerges as a main target for the regulation of the stiffness of striated muscle. In the last years, single-molecule experiments by Atomic Force Microscopy (AFM) have demonstrated that redox posttranslational modifications are strong modulators of the mechanical function of titin. Here, we provide an overview of the recent development of the redox mechanobiology of titin, and suggest avenues of research to better understand how the stiffness of molecules, cells and tissues are modulated by redox signaling in health and disease.
eng
Redox regulation of protein nanomechanics in health and disease: Lessons from titin
journal article
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URL
https://repisalud.isciii.es/bitstreams/2cd92ccc-269d-486f-8656-a6299345cf61/download
File
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application/pdf
RedoxRegulationProteinNanomechanics_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/4300f78f-9088-4b68-b636-bcdb4c177c0f/download
File
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text/plain
RedoxRegulationProteinNanomechanics_2019.pdf.txt