2026-05-20T23:32:03Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/71062024-09-27T16:16:35Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608

00925njm 22002777a 4500 dc García-Esquinas, Esther author Perez-Gomez, Beatriz author Fernandez-Navarro, Pablo L author Fernández, Mario Antonio author de Paz, Concha author Pérez-Meixeira, Ana María author Gil, Elisa author Iriso, Andrés author Sanz, Juan Carlos author Astray, Jenaro author Cisneros, Margot author de Santos, Amparo author Asensio, Angel author García-Sagredo, José Miguel author García, José Frutos author Vioque, Jesus author Lopez-Abente, Gonzalo author Pollan-Santamaria, Marina author González, María José author Martínez, Mercedes author Aragones, Nuria author 2013-09-12 BACKGROUND: In Spain, few studies have evaluated prenatal exposure to heavy metals. The objective of this study was to describe lead, mercury and cadmium concentrations in blood from a sample of newborn-mother-father trios, as well as to investigate the association between metals in cord blood and parental variables. We also explored the relationship between cord blood metal concentrations and child characteristics at birth. METHODS: Metal correlations among family members were assessed using Spearman Rank Correlation Coefficient. Linear regression was used to explore the association between parental variables and log-transformed cord blood lead and cord blood mercury concentrations. In the case of cadmium, tobit regression was used due to the existence of samples below the detection limit. The association between cord blood metal concentrations and child characteristics at birth was evaluated using linear regression. RESULTS: Geometric means for lead, mercury and cadmium were 14.09 μg/L, 6.72 μg/L and 0.27 μg/L in newborns; 19.80 μg/L, 3.90 μg/L and 0.53 μg/L in pregnant women; and 33.00 μg/L, 5.38 μg/L and 0.49 μg/L in men. Positive correlations were found between metal concentrations among members of the trio. Lead and cadmium concentrations were 15% and 22% higher in newborns from mothers who smoked during pregnancy, while mercury concentrations were 25% higher in newborns from mothers with greater fish intake. Cord-blood lead levels showed seasonal periodicity, with lower concentrations observed in winter. Cord blood cadmium concentrations over 0.29 μg/L were associated with lower 1-minute and 5-minute Apgar scores. CONCLUSIONS: These results reinforce the need to establish biomonitoring programs in Spain, and provide support for tobacco smoke and fish consumption as important preventable sources of heavy metal exposure in newborns. Additionally, our findings support the hypothesis that cadmium exposure might be deleterious to fetal development. BMC Public Health. 2013 Sep 12;13:841 10.1186/1471-2458-13-841 1471-2458 BMC public health 24028648 http://hdl.handle.net/20.500.12105/7106 Cadmium Lead Mercury Biomarker Environmental pollution Tobacco Pregnancy Lead, mercury and cadmium in umbilical cord blood and its association with parental epidemiological variables and birth factors