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oai:repisalud.isciii.es:20.500.12105/71042024-09-27T22:51:17Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc El Moussi, Awatef author Ben Hadj Kacem, Mohamed Ali author Pozo Sanchez, Francisco author Ledesma, Juan author Cuevas, Maria Teresa author Casas Flecha, Inmaculada author Slim, Amine author 2013-05-16 We present major results concerning isolation and determination of the nucleotide sequence of hemagglutinin (HA1) of the pandemic (H1N1)pdm09 influenza viruses found in Tunisia. Amino acid analysis revealed minor amino acid changes in the antigenic or receptor-binding domains. We found mutations that were also present in 1918 pandemic virus, which includes S183P in 4 and S185T mutation in 19 of 27 viruses analyzed from 2011, while none of the 2009 viruses carried these mutations. Also two specific amino acid differences into N-glycosylation sites (N288T and N276H) were detected. The phylogenetic analysis revealed that the majority of the Tunisian isolates clustered with clade A/St. Petersburg/27/2011 viruses characterized by D97N and S185T mutations. However it also reveals a trend of 2010 strains to accumulate amino acid variation and form new phylogenetic clade with three specific amino acid substitutions: V47I, E172K and K308E. Virol J. 2013 May 16;10:150. 10.1186/1743-422X-10-150 1743-422X Virology journal 23679923 http://hdl.handle.net/20.500.12105/7104 Antigenic site Glycosylation site Heammaglutinin Influenza A(H1N1)pdm09 Phylogeny Genetic diversity of HA1 domain of heammaglutinin gene of influenza A(H1N1)pdm09 in Tunisia