2026-06-14T03:29:48Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/70682025-04-24T17:55:13Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
de la Campa, Adela G
author
Ardanuy, Carmen
author
Balsalobre-Arenas, Maria Luz
author
Pérez-Trallero, Emilio
author
Marimón, José María
author
Fenoll, Asuncion
author
Liñares, Josefina
funder
Comunidad de Madrid (España)
funder
Ministerio de Ciencia e Innovación (España)
2019-02-01T15:58:28Z
2019-02-01T15:58:28Z
2009-06
Emerg Infect Dis. 2009;15(6):905-11.
10.3201/eid1506.080684
1080-6059
1080-6040
Emerging infectious diseases
19523289
http://hdl.handle.net/20.500.12105/7068
Among 4,215 Streptococcus pneumoniae isolates obtained in Spain during 2006, 98 (2.3%) were ciprofloxacin resistant (3.6% from adults and 0.14% from children). In comparison with findings from a 2002 study, global resistance remained stable. Low-level resistance (30 isolates with MIC 4-8 microg/mL) was caused by a reserpine-sensitive efflux phenotype (n = 4) or single topoisomerase IV (parC [n = 24] or parE [n = 1]) changes. One isolate did not show reserpine-sensitive efflux or mutations. High-level resistance (68 isolates with MIC >or=16 microg/mL) was caused by changes in gyrase (gyrA) and parC or parE. New changes in parC (S80P) and gyrA (S81V, E85G) were shown to be involved in resistance by genetic transformation. Although 49 genotypes were observed, clones Spain9V-ST156 and Sweden15A-ST63 accounted for 34.7% of drug-resistant isolates. In comparison with findings from the 2002 study, clones Spain14-ST17, Spain23F-ST81, and ST8819F decreased and 4 new genotypes (ST9710A, ST57016, ST43322, and ST71733) appeared in 2006.
eng
Changes in fluoroquinolone-resistant Streptococcus pneumoniae after 7-valent conjugate vaccination, Spain
research article
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URL
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File
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ChangesInFluoroquinoloneResistant_2009.pdf
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text/plain
ChangesInFluoroquinoloneResistant_2009.pdf.txt