2026-07-21T14:20:00Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/70612025-04-07T14:44:08Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud
author
Hernando Sebastian, Victoria
author
Alejos, Belén
author
Monge Corella, Susana
author
Berenguer, Juan
author
Anta, Lourdes
author
Vinuesa, David
author
Palacios, Rosario
author
Muga, Roberto
author
Moreno, Santiago
author
Jarrin Vera, Inmaculada
author
CoRIS Cohort
funder
Instituto de Salud Carlos III
2019-02-01T14:11:16Z
2019-02-01T14:11:16Z
2013-08-20
BMC Infect Dis. 2013 Aug 20;13:382.
10.1186/1471-2334-13-382
1471-2334
1471-2334
BMC infectious diseases
23961924
http://hdl.handle.net/20.500.12105/7061
BACKGROUND: Combination antiretroviral therapy (cART) has produced significant changes in mortality of HIV-infected persons. Our objective was to estimate mortality rates, standardized mortality ratios and excess mortality rates of cohorts of the AIDS Research Network (RIS) (CoRIS-MD and CoRIS) compared to the general population. METHODS: We analysed data of CoRIS-MD and CoRIS cohorts from 1997 to 2010. We calculated: (i) all-cause mortality rates, (ii) standardized mortality ratio (SMR) and (iii) excess mortality rates for both cohort for 100 person-years (py) of follow-up, comparing all-cause mortality with that of the general population of similar age and gender. RESULTS: Between 1997 and 2010, 8,214 HIV positive subjects were included, 2,453 (29.9%) in CoRIS-MD and 5,761 (70.1%) in CoRIS and 294 deaths were registered. All-cause mortality rate was 1.02 (95% CI 0.91-1.15) per 100 py, SMR was 6.8 (95% CI 5.9-7.9) and excess mortality rate was 0.8 (95% CI 0.7-0.9) per 100 py. Mortality was higher in patients with AIDS, hepatitis C virus (HCV) co-infection, and those from CoRIS-MD cohort (1997-2003). CONCLUSION: Mortality among HIV-positive persons remains higher than that of the general population of similar age and sex, with significant differences depending on the history of AIDS or HCV coinfection.
eng
All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997-2010
research article
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AllCauseMortalityIn_2013.pdf
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AllCauseMortalityIn_2013.pdf.txt