2026-07-21T14:57:28Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/70352024-09-27T20:22:09Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Martin, Virginie
author
Vouldoukis, Ioannis
author
Moreno, Javier
author
McGahie, David
author
Gueguen, Sylvie
author
Cuisinier, Anne-Marie
funder
Virbac (France)
2019-01-30T18:29:10Z
2019-01-30T18:29:10Z
2014-06-25
Vet Res. 2014 Jun 25;45:69.
10.1186/1297-9716-45-69
1297-9716
1297-9716
Veterinary research
24964736
http://hdl.handle.net/20.500.12105/7035
Control of canine leishmaniasis is an important objective for the benefit of dogs living in or visiting endemic areas and for public health because of the zoonotic nature of this disease. Resistance or susceptibility to developing canine leishmaniasis after exposure to Leishmania infantum is primarily determined by the ability of the immune system to develop an appropriate Th1-dominated specific response to the parasite. For this reason there is a need for effective canine vaccines that can decrease the number of dogs developing progressive infections. In this study, we followed the impact of the LiESP/QA-21 canine vaccine (composed of excreted-secreted proteins of L. infantum and the QA-21 saponin adjuvant), recently launched commercially in Europe, on selected humoral and cellular immune parameters following an infectious intravenous challenge with L. infantum promastigotes administered one year after the primary vaccine course. We also followed parasitological parameters to determine the parasitological status of the challenged dogs. In contrast to controls, vaccinated dogs retained significantly stronger cell-mediated immune responses against the parasite despite a virulent challenge and had significantly lower mean parasite burdens at the end of the study, associated with a lower probability of developing active infections. These results confirm that the immune responses generated by vaccination with LiESP/QA-21 are still effective against an intravenous challenge one year after the primary vaccine course.
eng
The protective immune response produced in dogs after primary vaccination with the LiESP/QA-21 vaccine (CaniLeish®) remains effective against an experimental challenge one year later
journal article
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URL
https://repisalud.isciii.es/bitstreams/22f41935-129f-42f7-b156-3726ff909ad1/download
File
MD5
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TheProtectiveImmuneResponse_2014.pdf
URL
https://repisalud.isciii.es/bitstreams/8e1ee78d-d540-49f8-86ef-6be31f366d10/download
File
MD5
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text/plain
TheProtectiveImmuneResponse_2014.pdf.txt