2026-05-22T17:23:50Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/70292024-09-27T21:00:20Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Bello, Gonzalo
author
Aulicino, Paula C
author
Ruchansky, Dora
author
Guimarães, Monick L
author
Lopez-Galindez, Luis Cecilio
author
Casado, Concepcion
author
Chiparelli, Hector
author
Rocco, Carlos
author
Mangano, Andrea
author
Sen, Luisa
author
Morgado, Mariza G
funder
National Council for Scientific and Technological Development (Brasil)
funder
Agencia Nacional de Promoción Científica y Tecnológica (Argentina)
funder
Instituto de Salud Carlos III
funder
Plan Nacional sobre el Sida (España)
2019-01-30T17:46:07Z
2019-01-30T17:46:07Z
2010-03-22
Retrovirology. 2010 Mar 22;7:22.
10.1186/1742-4690-7-22
1742-4690
1742-4690
Retrovirology
20307282
http://hdl.handle.net/20.500.12105/7029
BACKGROUND: Although HIV-1 CRF12_BF and CRF38_BF are two epidemiologically important recombinant lineages circulating in Argentina and Uruguay, little is known about their population dynamics. METHODS: A total of 120 "CRF12_BF-like" and 20 "CRF38_BF-like" pol recombinant sequences collected in Argentina and Uruguay from 1997 to 2009 were subjected to phylogenetic and Bayesian coalescent-based analyses to estimate evolutionary and demographic parameters. RESULTS: Phylogenetic analyses revealed that CRF12_BF viruses from Argentina and Uruguay constitute a single epidemic with multiple genetic exchanges among countries; whereas circulation of the CRF38_BF seems to be confined to Uruguay. The mean estimated substitution rate of CRF12_BF at pol gene (2.5 x 10-3 substitutions/site/year) was similar to that previously described for subtype B. According to our estimates, CRF12_BF and CRF38_BF originated at 1983 (1978-1988) and 1986 (1981-1990), respectively. After their emergence, the CRF12_BF and CRF38_BF epidemics seem to have experienced a period of rapid expansion with initial growth rates of around 1.2 year-1 and 0.9 year-1, respectively. Later, the rate of spread of these CRFs_BF seems to have slowed down since the mid-1990s. CONCLUSIONS: Our results suggest that CRF12_BF and CRF38_BF viruses were generated during the 1980s, shortly after the estimated introduction of subtype F1 in South America (~1975-1980). After an initial phase of fast exponential expansion, the rate of spread of both CRFs_BF epidemics seems to have slowed down, thereby following a demographic pattern that resembles those previously reported for the HIV-1 epidemics in Brazil, USA, and Western Europe.
eng
Phylodynamics of HIV-1 circulating recombinant forms 12_BF and 38_BF in Argentina and Uruguay
journal article
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PhylodynamicsOfHIV1Circulating_2010.pdf
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PhylodynamicsOfHIV1Circulating_2010.pdf.txt