2026-08-30T13:04:27Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/70222025-04-24T16:10:13Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16959col_20.500.12105_16962col_20.500.12105_16964col_20.500.12105_16968col_20.500.12105_16970col_20.500.12105_16974col_20.500.12105_16983
Repisalud
author
Dierssen-Sotos, Trinidad
author
Palazuelos-Calderón, Camilo
author
Jimenez-Moleon, Jose J.
author
Aragones, Nuria
author
Altzibar, Jone M
author
Castaño-Vinyals, Gemma
author
Martín-Sánchez, Vicente
author
Gómez-Acebo, Inés
author
Guevara, Marcela
author
Tardón, Adonina
author
Perez-Gomez, Beatriz
author
Amiano, Pilar
author
Moreno, Victor
author
Molina, Antonio J
author
Alonso-Molero, Jéssica
author
Moreno-Iribas, Conchi
author
Kogevinas, Manolis
author
Pollan-Santamaria, Marina
author
Llorca, Javier
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación Marqués de Valdecilla
funder
International Cancer Genome Consortium
funder
Junta de Castilla y León (España)
funder
Regional Government of Andalusia (España)
funder
Generalitat Valenciana (España)
funder
Fundación La Caixa
funder
Basque Government (España)
funder
Gobierno de la Región de Murcia (España)
funder
Unión Europea. Comisión Europea
funder
Asociación Española Contra el Cáncer
funder
Fundación Caja de Ahorros de Asturias
funder
University of Oviedo (España)
2019-01-30T12:58:10Z
2019-01-30T12:58:10Z
2018-03-12
BMC Cancer. 2018 Mar 12;18(1):280.
10.1186/s12885-018-4182-3
1471-2407
1471-2407
BMC cancer
29530003
http://hdl.handle.net/20.500.12105/7022
BACKGROUND: Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. METHODS: One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression. RESULTS: Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced. CONCLUSIONS: The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.
eng
Breast cancer
Genetic interactions
Reproductive factors
Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project
research article
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ReproductiveRiskFactorsIn_2018.pdf
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https://repisalud.isciii.es/bitstreams/c81cbb09-cc23-4d8a-af8a-0f57377513dc/download
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text/plain
ReproductiveRiskFactorsIn_2018.pdf.txt