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oai:repisalud.isciii.es:20.500.12105/70222025-04-24T16:10:13Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16959col_20.500.12105_16962col_20.500.12105_16964col_20.500.12105_16968col_20.500.12105_16970col_20.500.12105_16974col_20.500.12105_16983

00925njm 22002777a 4500 dc Dierssen-Sotos, Trinidad author Palazuelos-Calderón, Camilo author Jimenez-Moleon, Jose J. author Aragones, Nuria author Altzibar, Jone M author Castaño-Vinyals, Gemma author Martín-Sánchez, Vicente author Gómez-Acebo, Inés author Guevara, Marcela author Tardón, Adonina author Perez-Gomez, Beatriz author Amiano, Pilar author Moreno, Victor author Molina, Antonio J author Alonso-Molero, Jéssica author Moreno-Iribas, Conchi author Kogevinas, Manolis author Pollan-Santamaria, Marina author Llorca, Javier author 2018-03-12 BACKGROUND: Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. METHODS: One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression. RESULTS: Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced. CONCLUSIONS: The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect. BMC Cancer. 2018 Mar 12;18(1):280. 10.1186/s12885-018-4182-3 1471-2407 1471-2407 BMC cancer 29530003 http://hdl.handle.net/20.500.12105/7022 Breast cancer Genetic interactions Reproductive factors Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project