2026-07-21T14:27:07Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/70152024-11-29T16:01:38Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Cifdaloz, Metehan
author
Osterloh, Lisa
author
Graña Castro, Osvaldo
author
Riveiro-Falkenbach, Erica
author
Ximenez-Embun, Pilar
author
Muoz Peralta, Javier
author
Tejedo, Cristina
author
Calvo, Tonantzin G
author
Karras, Panagiotis
author
Olmeda, David
author
Miñana, Belén
author
Gómez-López, Gonzalo
author
Cañón, Estela
author
Eyras, Eduardo
author
Guo, Haihong
author
Kappes, Ferdinand
author
Ortiz-Romero, Pablo L
author
Rodríguez-Peralto, Jose L
author
Megias Vazquez, Diego
author
Valcárcel, Juan
author
Soengas, MS
funder
Ministerio de Ciencia e Innovación (España)
funder
Botín Foundation
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Ministerio de Sanidad y Consumo (España)
funder
Fundación La Caixa
funder
Fundación La Marató TV3
funder
Asociación Española Contra el Cáncer
funder
Fundación Mutua Madrileña
2019-01-28T12:54:54Z
2019-01-28T12:54:54Z
2017
Nat Commun. 2017; 8(1):2249.
10.1038/s41467-017-02353-y
2041-1723
2041-1723
Nature communications
29269732
http://hdl.handle.net/20.500.12105/7015
Melanomas are well-known for their altered mRNA expression profiles. Yet, the specific contribution of mRNA binding proteins (mRBPs) to melanoma development remains unclear. Here we identify a cluster of melanoma-enriched genes under the control of CUGBP Elav-like family member 1 (CELF1). CELF1 was discovered with a distinct prognostic value in melanoma after mining the genomic landscape of the 692 known mRBPs across different cancer types. Genome-wide transcriptomic, proteomic, and RNA-immunoprecipitation studies, together with loss-of-function analyses in cell lines, and histopathological evaluation in clinical biopsies, revealed an intricate repertoire of CELF1-RNA interactors with minimal overlap with other malignancies. This systems approach uncovered the oncogene DEK as an unexpected target and downstream effector of CELF1. Importantly, CELF1 and DEK were found to represent early-induced melanoma genes and adverse indicators of overall patient survival. These results underscore novel roles of CELF1 in melanoma, illustrating tumor type-restricted functions of RBPs in cancer.
eng
Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1
journal article
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