2026-06-14T12:11:35Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/70022025-01-23T09:00:33Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Rojas-Cabañeros, Jose Maria
author
Oliva-Martinez, Jose Luis
author
Santos, Eugenio
funder
Instituto de Salud Carlos III
funder
Red Temática de Investigación Cooperativa en Cáncer (RTICC) (España)
funder
Asociación Española Contra el Cáncer
funder
Junta de Castilla y León (España)
2019-01-11T15:31:49Z
2019-01-11T15:31:49Z
2011-03
Genes Cancer. 2011;2(3):298-305
10.1177/1947601911408078
1947-6027
1947-6019
Genes & cancer
https://pmc.ncbi.nlm.nih.gov/articles/PMC3128634/
21779500
http://hdl.handle.net/20.500.12105/7002
The Son of Sevenless (Sos) factors were originally discovered 2 decades ago as specialized Ras activators in signaling pathways controlling the process of R7 cell development in the eye of Drosophila melanogaster. The 2 known members of the mammalian Sos family (Sos1 and Sos2) code for ubiquitously expressed, highly homologous (69% overall) proteins involved in coupling signals originated by cell surface receptor tyrosine kinases (RTKs) to downstream, Ras-dependent mitogenic signaling pathways. Mechanistically, the Sos proteins function as enzymatic factors interacting with Ras proteins in response to upstream stimuli to promote guanine nucleotide exchange (GDP/GTP) and subsequent formation of the active Ras-GTP complex. In this review, we summarize current knowledge on structural, regulatory, and functional aspects of the Sos family, focusing on specific aspects of Sos biology such as structure-function relationship, crosstalk with different signaling pathways, and in vivo functional significance as deduced from phenotypic characterization of Sos knockout mice and human genetic syndromes caused by germline hSos1 mutations.
eng
RTK
Ras
Ras-GEF
Sos
signaling
Mammalian son of sevenless Guanine nucleotide exchange factors: old concepts and new perspectives
journal article
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