2026-04-29T04:08:57Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/69722025-06-26T10:08:23Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Vega Rocha, Yolanda
author
Delgado, Elena
author
Fernandez-Garcia, Aurora
author
Cuevas, Maria Teresa
author
Thomson, Michael M
author
Montero, Vanessa
author
Sanchez-Martinez, Monica
author
Sánchez, Ana Maria
author
Perez-Alvarez, Lucia
funder
Xunta de Galicia (España)
funder
Basque Government (España)
funder
Ministerio de Sanidad, Servicios Sociales e Igualdad (España)
2018-12-28T10:32:20Z
2018-12-28T10:32:20Z
2015-05-26
PLoS One. 2015 May 26;10(5):e0125699
1932-6203
http://hdl.handle.net/20.500.12105/6972
26010948
10.1371/journal.pone.0125699
1932-6203
PloS one
Our objectives were to carry out an epidemiological surveillance study on transmitted drug resistance (TDR) among individuals newly diagnosed of HIV-1 infection during a nine year period in Spain and to assess the role of transmission clusters (TC) in the propagation of resistant strains. An overall of 1614 newly diagnosed individuals were included in the study from January 2004 through December 2012. Individuals come from two different Spanish regions: Galicia and the Basque Country. Resistance mutations to reverse transcriptase inhibitors (RTI) and protease inhibitors (PI) were analyzed according to mutations included in the surveillance drug-resistance mutations list updated in 2009. TC were defined as those comprising viruses from five or more individuals whose sequences clustered in maximum likelihood phylogenetic trees with a bootstrap value ≥90%. The overall prevalence of TDR to any drug was 9.9%: 4.9% to nucleoside RTIs (NRTIs), 3.6% to non-nucleoside RTIs (NNRTIs), and 2.7% to PIs. A significant decrease of TDR to NRTIs over time was observed [from 10% in 2004 to 2% in 2012 (p=0.01)]. Sixty eight (42.2%) of 161 sequences with TDR were included in 25 TC composed of 5 or more individuals. Of them, 9 clusters harbored TDR associated with high level resistance to antiretroviral drugs. T215D revertant mutation was transmitted in a large cluster comprising 25 individuals. The impact of epidemiological networks on TDR frequency may explain its persistence in newly diagnosed individuals. The knowledge of the populations involved in TC would facilitate the design of prevention programs and public health interventions.
eng
Epidemiological Surveillance of HIV-1 Transmitted Drug Resistance in Spain in 2004-2012: Relevance of Transmission Clusters in the Propagation of Resistance Mutations
research article
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EpidemiologicalSurveillanceOfHIV-1_2015.pdf
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https://repisalud.isciii.es/bitstreams/927c371b-6275-4e53-85ae-5553d6baf7a7/download
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EpidemiologicalSurveillanceOfHIV-1_2015.pdf.txt