2026-07-22T09:50:25Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/69382024-09-27T20:09:22Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Gil, Horacio author Escudero, Raquel author Pons, Inmaculada author Rodriguez-Vargas, Manuela author Garcia-Esteban, Coral author Rodriguez-Moreno, Isabel author Garcia-Amil, Cristina author Lobo, Bruno author Valcárcel, Félix author Pérez, Azucena author Jiménez, Santos author Jado, Isabel author Juste, Ramón author Segura, Ferrán author Anda, Pedro author 2013-07-09 We have studied the diversity of B. henselae circulating in patients, reservoir hosts and vectors in Spain. In total, we have fully characterized 53 clinical samples from 46 patients, as well as 78 B. henselae isolates obtained from 35 cats from La Rioja and Catalonia (northeastern Spain), four positive cat blood samples from which no isolates were obtained, and three positive fleas by Multiple Locus Sequence Typing and Multiple Locus Variable Number Tandem Repeats Analysis. This study represents the largest series of human cases characterized with these methods, with 10 different sequence types and 41 MLVA profiles. Two of the sequence types and 35 of the profiles were not described previously. Most of the B. henselae variants belonged to ST5. Also, we have identified a common profile (72) which is well distributed in Spain and was found to persist over time. Indeed, this profile seems to be the origin from which most of the variants identified in this study have been generated. In addition, ST5, ST6 and ST9 were found associated with felines, whereas ST1, ST5 and ST8 were the most frequent sequence types found infecting humans. Interestingly, some of the feline associated variants never found on patients were located in a separate clade, which could represent a group of strains less pathogenic for humans. PLoS One. 2013 Jul 9;8(7):e68248 10.1371/journal.pone.0068248 1932-6203 1932-6203 PloS one 23874563 http://hdl.handle.net/20.500.12105/6938 Distribution of Bartonella henselae variants in patients, reservoir hosts and vectors in Spain