2026-06-14T03:36:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/69312025-04-08T09:26:05Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Casado, Concepcion
author
Colombo, Sara
author
Rauch, Andri
author
Martínez, Raquel
author
Günthard, Huldrych F
author
García, Soledad
author
Rodríguez, Carmen
author
Del Romero, Jorge
author
Telenti, Amalio
author
Lopez-Galindez, Luis Cecilio
funder
Instituto de Salud Carlos III
funder
Fundación para la Investigación y la Prevención del Sida en España
funder
Swiss National Science Foundation
2018-12-21T11:29:55Z
2018-12-21T11:29:55Z
2010-06-11
PLoS One. 2010 Jun 11;5(6):e11079.
10.1371/journal.pone.0011079
1932-6203
1932-6203
PloS one
20552027
http://hdl.handle.net/20.500.12105/6931
Background: Various patterns of HIV-1 disease progression are described in clinical practice and in research. There is a need to assess the specificity of commonly used definitions of long term non-progressor (LTNP) elite controllers (LTNP-EC), viremic controllers (LTNP-VC), and viremic non controllers (LTNP-NC), as well as of chronic progressors (P) and rapid progressors (RP). Methodology and principal findings: We re-evaluated the HIV-1 clinical definitions, summarized in Table 1, using the information provided by a selected number of host genetic markers and viral factors. There is a continuous decrease of protective factors and an accumulation of risk factors from LTNP-EC to RP. Statistical differences in frequency of protective HLA-B alleles (p-0.01), HLA-C rs9264942 (p-0.06), and protective CCR5/CCR2 haplotypes (p-0.02) across groups, and the presence of viruses with an ancestral genotype in the "viral dating" (i.e., nucleotide sequences with low viral divergence from the most recent common ancestor) support the differences among principal clinical groups of HIV-1 infected individuals. Conclusions: A combination of host genetic and viral factors supports current clinical definitions that discriminate among patterns of HIV-1 progression. The study also emphasizes the need to apply a standardized and accepted set of clinical definitions for the purpose of disease stratification and research.
eng
Host and viral genetic correlates of clinical definitions of HIV-1 disease progression
research article
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URL
https://repisalud.isciii.es/bitstreams/7db89239-d1d4-48a5-bfd6-ed0e1db17920/download
File
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application/pdf
HostAndViralGenetic_2010.pdf
URL
https://repisalud.isciii.es/bitstreams/c073747a-82a5-4cd5-bc1c-551cf242ae89/download
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HostAndViralGenetic_2010.pdf.txt