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oai:repisalud.isciii.es:20.500.12105/69312025-04-08T09:26:05Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Casado, Concepcion author Colombo, Sara author Rauch, Andri author Martínez, Raquel author Günthard, Huldrych F author García, Soledad author Rodríguez, Carmen author Del Romero, Jorge author Telenti, Amalio author Lopez-Galindez, Luis Cecilio author 2010-06-11 Background: Various patterns of HIV-1 disease progression are described in clinical practice and in research. There is a need to assess the specificity of commonly used definitions of long term non-progressor (LTNP) elite controllers (LTNP-EC), viremic controllers (LTNP-VC), and viremic non controllers (LTNP-NC), as well as of chronic progressors (P) and rapid progressors (RP). Methodology and principal findings: We re-evaluated the HIV-1 clinical definitions, summarized in Table 1, using the information provided by a selected number of host genetic markers and viral factors. There is a continuous decrease of protective factors and an accumulation of risk factors from LTNP-EC to RP. Statistical differences in frequency of protective HLA-B alleles (p-0.01), HLA-C rs9264942 (p-0.06), and protective CCR5/CCR2 haplotypes (p-0.02) across groups, and the presence of viruses with an ancestral genotype in the "viral dating" (i.e., nucleotide sequences with low viral divergence from the most recent common ancestor) support the differences among principal clinical groups of HIV-1 infected individuals. Conclusions: A combination of host genetic and viral factors supports current clinical definitions that discriminate among patterns of HIV-1 progression. The study also emphasizes the need to apply a standardized and accepted set of clinical definitions for the purpose of disease stratification and research. PLoS One. 2010 Jun 11;5(6):e11079. 10.1371/journal.pone.0011079 1932-6203 1932-6203 PloS one 20552027 http://hdl.handle.net/20.500.12105/6931 Host and viral genetic correlates of clinical definitions of HIV-1 disease progression