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oai:repisalud.isciii.es:20.500.12105/69302025-06-12T15:38:36Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_19611col_20.500.12105_16960

00925njm 22002777a 4500 dc Herrador, Zaida author Fernandez-Martinez, Amalia author Gomez-Barroso, Diana author Leon-Gomez, Inmaculada author Vieira, Carmen author Muro, Antonio author Benito, Agustin author 2017-03-29 INTRODUCTION: Mediterranean spotted fever (MSF) is a zoonotic disease caused by Rickettsia conorii. In Spain, deficiencies in the official reporting result in misreporting of this disease. This study aims to describe the clinical and temporal-spatial characteristics of MSF hospitalizations between 1997 and 2014. MATERIALS AND METHODS: We performed a retrospective descriptive study using the Hospitalization Minimum Data Set (CMBD). All CMBD's hospital discharges with ICD-9 CM code 082.1 were analyzed. Hospitalization rates were calculated and clinical characteristics were described. Spatial distribution of cases and their temporal behavior were also assessed. RESULTS: A total of 4,735 hospitalizations with MSF diagnosis were recorded during the study period, out of which 62.2% were male, mean age of 48. Diabetes mellitus, alcohol dependence syndrome, and chronic liver disease occurred in 10.8%, 2.4% and 2.8% hospitalizations, respectively. The median annual hospitalization rate showed a decreasing trend from a maximum of 12.9 in 1997 to a minimum rate of 3.1 in 2014. Most admissions occurred during the summer, showing a significant annual seasonal behavior. Important regional differences were found. DISCUSSION: Although MSF hospitalization rates have decreased considerably, it remains a public health problem due to its severity and economic impact. Therefore, it would be desirable to improve its oversight and surveillance. PLoS One. 2017 Mar 29;12(3):e0174745. 10.1371/journal.pone.0174745 1932-6203 1932-6203 PloS one 28355307 http://hdl.handle.net/20.500.12105/6930 Mediterranean spotted fever in Spain, 1997-2014: Epidemiological situation based on hospitalization records