2026-06-30T03:03:31Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/69292024-11-28T17:50:20Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16961
Repisalud
author
Pernas, Maria
author
Sanchez-Merino, Victor
author
Casado, Concepcion
author
Merino-Mansilla, Alberto
author
Olivares, Isabel
author
Yuste-Herranz, Maria Eloisa
author
Lopez-Galindez, Luis Cecilio
funder
Fundación para la Investigación y la Prevención del Sida en España
funder
Red de Investigación Cooperativa en Investigación en Sida (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia y Tecnología (España)
2018-12-21T11:00:47Z
2018-12-21T11:00:47Z
2015-08-10
PLoS One. 2015 Aug 10;10(8):e0134054
10.1371/journal.pone.0134054
1932-6203
1932-6203
PloS one
26258485
http://hdl.handle.net/20.500.12105/6929
This study evaluated the neutralization breadth in dually infected (DI) HIV-1 long-term non-progressor elite controller patients (LTNP-EC) using a representative minipanel of 6 viruses from 5 different subtypes. Our results showed an improved neutralization breadth in DI LTNP-EC patients when compared with matched LTNP single-infected patients. The role of viral diversity in neutralization was estimated with the Shannon Entropy and the p-distance in viral quasispecies. We found a positive correlation between neutralization breadth and diversity within the viral quasispecies. This correlation could explain why a group of LTNP-EC patients developed a broad neutralizing response despite having undetectable levels of viremia.
eng
HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activity
journal article
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URL
https://repisalud.isciii.es/bitstreams/e3601d9f-c72a-45c5-8ec6-2958c7b7032e/download
File
MD5
c929a16898ab75b68aab103040ea3944
1687045
application/pdf
HIV-1 Dual Infected LTNP-EC.pdf
URL
https://repisalud.isciii.es/bitstreams/6596f3ff-467b-45ee-819a-05e0ea51f6d9/download
File
MD5
ae835cfbb2ca32af0111810db2f593bf
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text/plain
HIV-1 Dual Infected LTNP-EC.pdf.txt