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oai:repisalud.isciii.es:20.500.12105/69292024-11-28T17:50:20Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16961

00925njm 22002777a 4500 dc Pernas, Maria author Sanchez-Merino, Victor author Casado, Concepcion author Merino-Mansilla, Alberto author Olivares, Isabel author Yuste-Herranz, Maria Eloisa author Lopez-Galindez, Luis Cecilio author 2015-08-10 This study evaluated the neutralization breadth in dually infected (DI) HIV-1 long-term non-progressor elite controller patients (LTNP-EC) using a representative minipanel of 6 viruses from 5 different subtypes. Our results showed an improved neutralization breadth in DI LTNP-EC patients when compared with matched LTNP single-infected patients. The role of viral diversity in neutralization was estimated with the Shannon Entropy and the p-distance in viral quasispecies. We found a positive correlation between neutralization breadth and diversity within the viral quasispecies. This correlation could explain why a group of LTNP-EC patients developed a broad neutralizing response despite having undetectable levels of viremia. PLoS One. 2015 Aug 10;10(8):e0134054 10.1371/journal.pone.0134054 1932-6203 1932-6203 PloS one 26258485 http://hdl.handle.net/20.500.12105/6929 HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activity