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00925njm 22002777a 4500 dc Gómez-Acebo, Inés author Dierssen-Sotos, Trinidad author Palazuelos, Camilo author Perez-Gomez, Beatriz author Lope Carvajal, Virginia author Tusquets, Ignasi author Alonso, María Henar author Moreno, Victor author Amiano, Pilar author Molina de la Torre, Antonio José author Barricarte, Aurelio author Tardón, Adonina author Camacho, Antonio author Peiró-Pérez, Rosana author Marcos-Gragera, Rafael author Muñoz, Montse author Michelena-Echeveste, Maria Jesus author Ortega Valin, Luis author Guevara, Marcela author Castaño-Vinyals, Gemma author Aragones, Nuria author Kogevinas, Manolis author Pollan-Santamaria, Marina author Llorca, Javier author 2016-08-10 INTRODUCTION: The evidence on the relationship between breast cancer and different types of antihypertensive drugs taken for at least 5 years is limited and inconsistent. Furthermore, the debate has recently been fueled again with new data reporting an increased risk of breast cancer among women with a long history of use of antihypertensive drugs compared with nonusers. METHODS: In this case-control study, we report the antihypertensive drugs-breast cancer relationship in 1,736 breast cancer cases and 1,895 healthy controls; results are reported stratifying by the women's characteristics (i.e., menopausal status or body mass index category) tumor characteristics and length of use of antihypertensive drugs. RESULTS: The relationship among breast cancer and use of calcium channel blockers (CCB) for 5 or more years had odds ratio (OR) = 1.77 (95% CI, 0.99 to 3.17). Stratifying by BMI, the OR increased significantly in the group with BMI ≥ 25 (OR 2.54, 95% CI, 1.24 to 5.22). CCBs were even more strongly associated with more aggressive tumors, (OR for invasive tumors = 1.96, 95% CI = 1.09 to 3.53; OR for non ductal cancers = 3.97, 95% CI = 1.73 to 9.05; OR for Erbb2+ cancer = 2.97, 95% CI: 1.20 to 7.32). On the other hand, premenopausal women were the only group in which angiotensin II receptor blockers may be associated with breast cancer (OR = 4.27, 95% CI = 1.32 to 13.84) but this could not be identified with any type or stage. Use of angiotensin-converting-enzyme inhibitors, beta blockers and diuretics were not associated with risk. CONCLUSIONS: In this large population-based study we found that long term use of calcium channel blockers is associated with some subtypes of breast cancer (and with breast cancer in overweight women). PLoS One. 2016 Aug 10;11(8):e0159672 10.1371/journal.pone.0159672 1932-6203 1932-6203 PloS one 27508297 http://hdl.handle.net/20.500.12105/6925 The Use of Antihypertensive Medication and the Risk of Breast Cancer in a Case-Control Study in a Spanish Population: The MCC-Spain Study