2026-06-14T05:18:25Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/69222025-03-04T17:12:41Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Talbi, Chiraz author Lemey, Philippe author Suchard, Marc A author Abdelatif, Elbia author Elharrak, Mehdi author Nourlil, Jalal author Jalal, Nourlil author Faouzi, Abdellah author Echevarria, Juan Emilio author Vázquez-Morón, Sonia author Rambaut, Andrew author Campiz, Nicholas author Tatem, Andrew J author Holmes, Edward C author Bourhy, Hervé author 2010-10-28 Understanding the role of humans in the dispersal of predominantly animal pathogens is essential for their control. We used newly developed Bayesian phylogeographic methods to unravel the dynamics and determinants of the spread of dog rabies virus (RABV) in North Africa. Each of the countries studied exhibited largely disconnected spatial dynamics with major geopolitical boundaries acting as barriers to gene flow. Road distances proved to be better predictors of the movement of dog RABV than accessibility or raw geographical distance, with occasional long distance and rapid spread within each of these countries. Using simulations that bridge phylodynamics and spatial epidemiology, we demonstrate that the contemporary viral distribution extends beyond that expected for RABV transmission in African dog populations. These results are strongly supportive of human-mediated dispersal, and demonstrate how an integrated phylogeographic approach will turn viral genetic data into a powerful asset for characterizing, predicting, and potentially controlling the spatial spread of pathogens. PLoS Pathog. 2010 Oct 28;6(10):e1001166 10.1371/journal.ppat.1001166 1553-7374 1553-7374 PLoS pathogens 21060816 http://hdl.handle.net/20.500.12105/6922 Phylodynamics and human-mediated dispersal of a zoonotic virus