2026-05-17T00:18:31Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/69132024-09-27T21:59:21Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Rodriguez Martinez, Javier M
author
Moreno, Leticia Tais
author
Alejo, Alí
author
Lacasta, Anna
author
Rodríguez, Fernando
author
Salas, María L
funder
Ministerio de Economía y Competitividad (España)
funder
Fundación Ramón Areces
2018-12-19T12:41:11Z
2018-12-19T12:41:11Z
2015-11-30
PLoS One. 2015 Nov 30;10(11):e0142889
10.1371/journal.pone.0142889
1932-6203
1932-6203
PloS one
26618713
http://hdl.handle.net/20.500.12105/6913
The strain BA71V has played a key role in African swine fever virus (ASFV) research. It was the first genome sequenced, and remains the only genome completely determined. A large part of the studies on the function of ASFV genes, viral transcription, replication, DNA repair and morphogenesis, has been performed using this model. This avirulent strain was obtained by adaptation to grow in Vero cells of the highly virulent BA71 strain. We report here the analysis of the genome sequence of BA71 in comparison with that of BA71V. They possess the smallest genomes for a virulent or an attenuated ASFV, and are essentially identical except for a relatively small number of changes. We discuss the possible contribution of these changes to virulence. Analysis of the BA71 sequence allowed us to identify new similarities among ASFV proteins, and with database proteins including two ASFV proteins that could function as a two-component signaling network.
eng
Genome Sequence of African Swine Fever Virus BA71, the Virulent Parental Strain of the Nonpathogenic and Tissue-Culture Adapted BA71V
journal article
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URL
https://repisalud.isciii.es/bitstreams/eaf65a79-3dda-4cec-ac6e-e71e1f0066d2/download
File
MD5
31c130040b47961f339158a96b25606f
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application/pdf
GenomeSequenceofAfrican_2015.pdf
URL
https://repisalud.isciii.es/bitstreams/b7e8d105-7e84-42cd-a9d4-22315bbecc80/download
File
MD5
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text/plain
GenomeSequenceofAfrican_2015.pdf.txt