2026-07-23T20:21:44Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/68872025-04-10T12:03:32Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud
author
Reichmann, Heinz
author
Cooper, James
author
Rolfe, Katie
author
Martínez-Martín, Pablo
funder
GlaxoSmithKline
funder
SkyePharma
2018-12-18T14:23:37Z
2018-12-18T14:23:37Z
2011
Parkinsons Dis. 2011; 2011:354760
10.4061/2011/354760
2042-0080
Parkinson's disease
21687750
http://hdl.handle.net/20.500.12105/6887
Patients undergoing long-term therapy for PD often experience motor fluctuations and nocturnal disturbances. In a post-hoc analysis, we explored effects of ropinirole prolonged release on sleep, night-time awakenings, and "on" time over 24 hours. Patients with advanced PD suboptimally controlled with L-dopa were randomized to adjunctive ropinirole prolonged release (2-24 mg/day) or placebo for 24 weeks. Awake/asleep and, if awake, "on"/"off" status was recorded via diary cards. At week 24 last observation carried forward, changes in nighttime or daytime sleep duration were not significantly different between treatments. Of patients with baseline awakenings, a significantly higher proportion in the ropinirole prolonged release group had a reduction in awakenings versus placebo. Patients receiving ropinirole prolonged release had a significantly greater increase in amount/percentage of awake time "on"/"on" without troublesome dyskinesia during all periods assessed (including night-time and early morning), versus placebo, and higher odds for being "on" on waking. Adjunctive once-daily ropinirole prolonged release may help provide 24-hour symptom control in patients with advanced PD not optimally controlled with L-dopa.
eng
Sleep Duration and "on" Time during Different Periods of the Day and Night in Patients with Advanced Parkinson's Disease Receiving Adjunctive Ropinirole Prolonged Release
research article
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URL
https://repisalud.isciii.es/bitstreams/b3d6ef33-da72-4aa8-b546-3fd2e7ac1655/download
File
MD5
203c7b173022e64ad848fc44662e8381
847232
application/pdf
SleepDurationAndOn_2011.pdf
URL
https://repisalud.isciii.es/bitstreams/ae13fee6-93a6-4eb1-8c78-12eeb9019d4c/download
File
MD5
ba12bf262f3c5d9a164afca50638e00c
35475
text/plain
SleepDurationAndOn_2011.pdf.txt