2026-05-17T01:41:13Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/68702024-11-29T14:30:16Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_2173col_20.500.12105_19605col_20.500.12105_19597
Repisalud
author
Alonso-Gonzalez, Noelia
author
Quintana, Juan A.
author
García-Silva, Susana
author
Mazariegos, Marina
author
Gonzalez de la Aleja, Arturo
author
Nicolas-Avila, Jose A.
author
Walter, Wencke
author
Adrover, Jose M
author
Crainiciuc, Georgiana
author
Kuchroo, Vijay K
author
Rothlin, Carla V
author
Peinado Selgas , Hector
author
Castrillo, Antonio
author
Ricote, Mercedes
author
Hidalgo, Andres
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Unión Europea. Comisión Europea
funder
National Institutes of Health (Estados Unidos)
funder
Atresmedia
funder
Asociación Española Contra el Cáncer
funder
Worldwide Cancer Research
funder
Fundación ProCNIC
2018-12-17T13:18:03Z
2018-12-17T13:18:03Z
2017-05-01
J Exp Med. 2017; 214(5):1281-1296
10.1084/jem.20161375
1540-9538
0022-1007
The Journal of experimental medicine
28432199
http://hdl.handle.net/20.500.12105/6870
Tissue-resident macrophages display varying phenotypic and functional properties that are largely specified by their local environment. One of these functions, phagocytosis, mediates the natural disposal of billions of cells, but its mechanisms and consequences within living tissues are poorly defined. Using a parabiosis-based strategy, we identified and isolated macrophages from multiple tissues as they phagocytosed blood-borne cellular material. Phagocytosis was circadianally regulated and mediated by distinct repertoires of receptors, opsonins, and transcription factors in macrophages from each tissue. Although the tissue of residence defined the core signature of macrophages, phagocytosis imprinted a distinct antiinflammatory profile. Phagocytic macrophages expressed CD206, displayed blunted expression of Il1b, and supported tissue homeostasis. Thus, phagocytosis is a source of macrophage heterogeneity that acts together with tissue-derived factors to preserve homeostasis.
eng
Phagocytosis imprints heterogeneity in tissue-resident macrophages
journal article
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PhagocytosisImprintsHeterogeneity_2017.pdf
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PhagocytosisImprintsHeterogeneity_2017.pdf.txt