2026-05-17T01:18:43Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/68702024-11-29T14:30:16Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_2173col_20.500.12105_19605col_20.500.12105_19597

00925njm 22002777a 4500 dc Alonso-Gonzalez, Noelia author Quintana, Juan A. author García-Silva, Susana author Mazariegos, Marina author Gonzalez de la Aleja, Arturo author Nicolas-Avila, Jose A. author Walter, Wencke author Adrover, Jose M author Crainiciuc, Georgiana author Kuchroo, Vijay K author Rothlin, Carla V author Peinado Selgas , Hector author Castrillo, Antonio author Ricote, Mercedes author Hidalgo, Andres author 2017-05-01 Tissue-resident macrophages display varying phenotypic and functional properties that are largely specified by their local environment. One of these functions, phagocytosis, mediates the natural disposal of billions of cells, but its mechanisms and consequences within living tissues are poorly defined. Using a parabiosis-based strategy, we identified and isolated macrophages from multiple tissues as they phagocytosed blood-borne cellular material. Phagocytosis was circadianally regulated and mediated by distinct repertoires of receptors, opsonins, and transcription factors in macrophages from each tissue. Although the tissue of residence defined the core signature of macrophages, phagocytosis imprinted a distinct antiinflammatory profile. Phagocytic macrophages expressed CD206, displayed blunted expression of Il1b, and supported tissue homeostasis. Thus, phagocytosis is a source of macrophage heterogeneity that acts together with tissue-derived factors to preserve homeostasis. J Exp Med. 2017; 214(5):1281-1296 10.1084/jem.20161375 1540-9538 0022-1007 The Journal of experimental medicine 28432199 http://hdl.handle.net/20.500.12105/6870 Phagocytosis imprints heterogeneity in tissue-resident macrophages