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00925njm 22002777a 4500 dc Li, Jackson LiangYao author Zarbock, Alexander author Hidalgo, Andres author 2017-07-18 Platelets participate in many important physiological processes, including hemostasis and immunity. However, despite their broad participation in these evolutionarily critical roles, the anucleate platelet is uniquely mammalian. In contrast with the large nucleated equivalents in lower vertebrates, we find that the design template for the evolutionary specialization of platelets shares remarkable similarities with human-engineered unmanned aerial vehicles in terms of overall autonomy, maneuverability, and expendability. Here, we review evidence illustrating how platelets are uniquely suited for surveillance and the manner in which they consequently provide various types of support to other cell types. J Exp Med. 2017; 214(8):2193 10.1084/jem.20170879 1540-9538 0022-1007 The Journal of experimental medicine 28720569 http://hdl.handle.net/20.500.12105/6864 Platelets as autonomous drones for hemostatic and immune surveillance