2026-08-05T09:54:40Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/68632024-09-27T08:05:21Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Nicolas-Avila, Jose A.
author
Hidalgo, Andres
author
Ballesteros, Ivan
funder
Fundación La Marató TV3
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
2018-12-17T10:49:05Z
2018-12-17T10:49:05Z
2018-10
J Leukoc Biol. 2018; 104(4):743-753
10.1002/JLB.6MR0118-041R
1938-3673
0741-5400
Journal of leukocyte biology
29947422
http://hdl.handle.net/20.500.12105/6863
The functions of macrophages in healthy tissues extend beyond their well-established roles as immune sentinels and effectors. Among tissues, cells of the brain and heart possess unique excitatory properties that likely demand special support. Accordingly, existing evidence demonstrates that microglia in the brain has an active role in synaptic organization, control of neuronal excitability, phagocytic removal of debris, and trophic support during brain development. In the heart, recent studies suggest that cardiac macrophages are involved in the regulation of heart homeostasis by phagocytosis, production of trophic, and immune-related factors, and by forming direct contacts with cardiomyocytes to regulate electrical conduction. In this review, we discuss mechanisms associated with the high degree of specialization of resident macrophages in both tissues, their origin and heterogeneity, and their contributions in regulating homeostasis under steady-state and pathological conditions.
eng
brain
circulatory/cardiac
innate cell mediated immunity
monocytes/macrophages
myeloid cells
Specialized functions of resident macrophages in brain and heart
journal article
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URL
https://repisalud.isciii.es/bitstreams/ee11e0e8-ea9d-4891-a87a-29fe61ff6122/download
File
MD5
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application/pdf
JLB Manuscript_Final.pdf
URL
https://repisalud.isciii.es/bitstreams/4ecda5da-1df7-4723-b57d-8c2ae60d9204/download
File
MD5
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text/plain
JLB Manuscript_Final.pdf.txt