2026-06-14T05:05:06Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/68532025-04-10T12:07:24Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Montalvo-Alvarez, Ana M
author
Folgueira, Cristina
author
Carrión, Javier
author
Monzote-Fidalgo, Lianet
author
Cañavate, Carmen
author
Requena, Jose M
funder
Ministerio de Ciencia y Tecnología (España)
funder
Instituto de Salud Carlos III
funder
Centro de Estudios de América Latina
2018-12-14T10:08:52Z
2018-12-14T10:08:52Z
2008
J Biomed Biotechnol. 2008;2008:695432.
10.1155/2008/695432
1110-7251
1110-7243
Journal of biomedicine & biotechnology
18401455
http://hdl.handle.net/20.500.12105/6853
Protozoa of the genus Leishmania are causative agents of leishmaniasis, an important health problem in both human and veterinary medicine. Here, we describe a new heat shock protein (HSP) in Leishmania, belonging to the small HSP (sHSP) family in kinetoplastids. The protein is highly conserved in different Leishmania species, showing instead significant divergence with sHSP's from other organisms. The humoral response elicited against this protein during Leishmania infection has been investigated in natural infected humans and dogs, and in experimentally infected hamsters. Leishmania HSP20 is a prominent antigen for canine hosts; on the contrary, the protein seems to be a poor antigen for human immune system. Time-course analysis of appearance of anti-HSP20 antibodies in golden hamsters indicated that these antibodies are produced at late stages of the infection, when clinical symptoms of disease are patent. Finally, the protective efficacy of HSP20 was assessed in mice using a DNA vaccine approach prior to challenge with Leishmania amazonensis.
eng
The Leishmania HSP20 is antigenic during natural infections, but, as DNA vaccine, it does not protect BALB/c mice against experimental L. amazonensis infection
research article
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URL
https://repisalud.isciii.es/bitstreams/e0f069e5-b3e6-453b-9b86-b9a50111d225/download
File
MD5
63ca84f9927698a970671a3dcb2b927a
925444
application/pdf
TheLeishmaniaHSP20Is_2008.pdf
URL
https://repisalud.isciii.es/bitstreams/671bb7f3-73ed-4eb0-82a3-24bab847c468/download
File
MD5
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text/plain
TheLeishmaniaHSP20Is_2008.pdf.txt