2026-06-14T03:29:06Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/68522024-11-29T16:00:07Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_2173col_20.500.12105_19605col_20.500.12105_19597
Repisalud
author
Casanova-Acebes, Maria
author
Nicolas-Avila, Jose A.
author
Li, Jackson LiangYao
author
García-Silva, Susana
author
Balachander, Akhila
author
Rubio-Ponce, Andrea
author
Weiss, Linnea A
author
Adrover, Jose M
author
Burrows, Kyle
author
Alonso-Gonzalez, Noelia
author
Ballesteros, Ivan
author
Devi, Sapna
author
Quintana, Juan A.
author
Crainiciuc, Georgiana
author
Leiva, Magdalena
author
Gunzer, Matthias
author
Weber, Christian
author
Nagasawa, Takashi
author
Soehnlein, Oliver
author
Merad, Miriam
author
Mortha, Arthur
author
Ng, Lai Guan
author
Peinado Selgas , Hector
author
Hidalgo, Andres
funder
Deutsche Forschungsgemeinschaft (Alemania)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Comunidad de Madrid (España)
funder
Canadian Institutes of Health Research
funder
Fundación ProCNIC
2018-12-13T14:46:14Z
2018-12-13T14:46:14Z
2018-11-05
J Exp Med. 2018; 215(11):2778-95
10.1084/jem.20181468
1540-9538
0022-1007
The Journal of experimental medicine
30282719
http://hdl.handle.net/20.500.12105/6852
Immune protection relies on the capacity of neutrophils to infiltrate challenged tissues. Naive tissues, in contrast, are believed to remain free of these cells and protected from their toxic cargo. Here, we show that neutrophils are endowed with the capacity to infiltrate multiple tissues in the steady-state, a process that follows tissue-specific dynamics. By focusing in two particular tissues, the intestine and the lungs, we find that neutrophils infiltrating the intestine are engulfed by resident macrophages, resulting in repression of Il23 transcription, reduced G-CSF in plasma, and reinforced activity of distant bone marrow niches. In contrast, diurnal accumulation of neutrophils within the pulmonary vasculature influenced circadian transcription in the lungs. Neutrophil-influenced transcripts in this organ were associated with carcinogenesis and migration. Consistently, we found that neutrophils dictated the diurnal patterns of lung invasion by melanoma cells. Homeostatic infiltration of tissues unveils a facet of neutrophil biology that supports organ function, but can also instigate pathological states.
eng
Neutrophils instruct homeostatic and pathological states in naive tissues
journal article
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The Journal of experimental medicine 2018 Casa-2.pdf
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https://repisalud.isciii.es/bitstreams/71778826-4772-4af3-a4c9-ac8e5afa51da/download
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The Journal of experimental medicine 2018 Casa-2.pdf.txt