2026-06-14T06:44:07Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/68342024-11-28T17:55:06Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16961
Repisalud
author
Garriga, Cesar
author
García de Olalla, Patricia
author
Miró, Josep M
author
Ocaña, Inma
author
Knobel, Hernando
author
Barbera, Maria Jesus
author
Humet, Victoria
author
Domingo, Pere
author
Gatell, Josep M
author
Ribera, Esteve
author
Gurguí, Mercè
author
Marco, Andrés
author
Caylà, Joan A
funder
Instituto de Salud Carlos III
2018-12-13T09:57:01Z
2018-12-13T09:57:01Z
2015-12-30
PLoS One. 2015 Dec 30;10(12):e0145701.
10.1371/journal.pone.0145701
1932-6203
PloS one
26716982
http://hdl.handle.net/20.500.12105/6834
INTRODUCTION: Antiretroviral therapy has led to a decrease in HIV-related mortality and to the emergence of non-AIDS defining diseases as competing causes of death. This study estimates the HIV mortality rate and their risk factors with regard to different causes in a large city from January 2001 to June 2013. MATERIALS AND METHODS: We followed-up 3137 newly diagnosed HIV non-AIDS cases. Causes of death were classified as HIV-related, non-HIV-related and external. We examined the effect of risk factors on survival using mortality rates, Kaplan-Meier plots and Cox models. Finally, we estimated survival for each main cause of death groups through Fine and Gray models. MORTALITY RESULTS: 182 deaths were found [14.0/1000 person-years of follow-up (py); 95% confidence interval (CI):12.0-16.1/1000 py], 81.3% of them had a known cause of death. Mortality rate by HIV-related causes and non-HIV-related causes was the same (4.9/1000 py; CI:3.7-6.1/1000 py), external was lower [1.7/1000 py; (1.0-2.4/1000 py)]. SURVIVAL RESULTS: Kaplan-Meier estimate showed worse survival in intravenous drug user (IDU) and heterosexuals than in men having sex with men (MSM). Factors associated with HIV-related causes of death include: IDU male (subHazard Ratio (sHR):3.2; CI:1.5-7.0) and <200 CD4 at diagnosis (sHR:2.7; CI:1.3-5.7) versus ≥500 CD4. Factors associated with non-HIV-related causes of death include: ageing (sHR:1.5; CI:1.4-1.7) and heterosexual female (sHR:2.8; CI:1.1-7.3) versus MSM. Factors associated with external causes of death were IDU male (sHR:28.7; CI:6.7-123.2) and heterosexual male (sHR:11.8; CI:2.5-56.4) versus MSM. CONCLUSION AND RECOMMENDATION: There are important differences in survival among transmission groups. Improved treatment is especially necessary in IDUs and heterosexual males.
eng
Mortality, Causes of Death and Associated Factors Relate to a Large HIV Population-Based Cohort
research article
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https://repisalud.isciii.es/bitstreams/d3994b18-a930-46dc-a5e6-3b5070c49b3b/download
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application/pdf
MortalityCausesOfDeath_2015.pdf
URL
https://repisalud.isciii.es/bitstreams/191c8661-ef47-4dee-a984-9f7956ce71f5/download
File
MD5
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text/plain
MortalityCausesOfDeath_2015.pdf.txt